REQ-10058392
7月 23, 2025
USA

摘要

#LI-Hybrid

This position will be on-site in Cambridge, MA and will not have the ability to be located remotely.

In the Director in PK Sciences you will provide ADME /PK/PKPD project support to the Neuroscience Therapeutic Area contributing to projects from Discovery to IND filing and First-in-Human studies and beyond. In this unique role you will collaborate and partner with PK Sciences functions including in vitro and in vivo ADME, biotransformation, bioanalytics and modeling & simulation and represent the PK Sciences organization within project teams.

About the Role

Key Responsibilities:

  • Support teams in developing the strategy for, and coordinate the implementation of, the characterization and selection of lead compounds and drug candidates with favorable PK/ADME properties, elucidate PK/PD relationships driving efficacy/safety and contribute to human PK prediction and dose and regimen selection. 
  • Provide matrixed leadership across the organization to align and influence across the cross-functional team to identify and mitigate key project issues related to the pharmacokinetic sciences [PKS] discipline (PK, PK/PD, metabolism and clinical pharmacology). 
  • Proactively contribute to developing drug candidates across the Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology input. 
  • Be responsible for the PK, PK/PD and M&S component of study protocols, reports, project summaries and development plans, and author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPDs/NDAs/BLAs within agreed timelines and which meet regulatory requirements as well as prepare appropriate responses to Health Authority questions (globally). 
  • Oversee or perform PK and PK/PD analyses using a variety of tools and approaches and integrate, interpret and report data to project teams and other customers. Our organization further offers the opportunity to seamlessly gain exposure to different stages of development, different drug modalities and cross-train in multiple indications.

Essential Requirements: 

  • Ph.D. or Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related biologic background.
  • A minimum of 10 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma) including 5 plus years of experience in a lead role overseeing DMPK/Clinical Pharmacology project strategy, either in discovery or clinical development.
  • Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences.
  • Proficient in the application of PK and PK/PD analysis with working knowledge of software such as WINNONLIN/Phoenix
  • Hands-on project experience with compounds of various modalities including low molecular weight and biologics drug discovery and development.
  • Proven record as leader with good negotiation, organizational and project management skills.
  • Strong coaching and mentoring skills desired. 
  • Demonstrated success in working in a cross-functional, matrixed, project-team environment.

The salary for this position is expected to range between $185,500 and $344,500 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? http://www.novartis.com/about/strategy/people-and-culture

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Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: http://www.novartis.com/careers/benefits-rewards

Biomedical Research
Pharma Research
USA
Massachusetts
Cambridge (USA)
Research & Development
Full time
Regular
No
A female Novartis scientist wearing a white lab coat and glasses, smiles in front of laboratory equipment.
REQ-10058392

Director, PK Sciences Neuroscience Therapeutic Area

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